The Muscarinic Receptors (The Receptors)


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Genes that share disorders with CHRM1: view. Peptide ligand-binding receptors. RET signaling. ENSP 21 P G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger.


  • History of Research on Nicotinic and Muscarinic Cholinergic Receptors | SpringerLink.
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  • Muscarinic acetylcholine receptor.
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Case Studies in Environmental Medicine (CSEM)

Xanomeline oxalate. Aclidinium Bromide. AF-DX Arecaidine butynyl ester tosylate. Arecaidine propargyl ester tosylate.

Acetylcholine receptors (muscarinic) | Introduction | BPS/IUPHAR Guide to PHARMACOLOGY

Arecoline hydrobromide. Bethanechol chloride. Biperiden HCl. Cevimeline hydrochloride hemihydrate. Darifenacin HBr. DAU hydrochloride. Dicyclomine HCl. Diphenylpyraline HCl. Fesoterodine Fumarate. Homatropine Bromide. Homatropine Methylbromide. J fumarate.

Mepenzolate Bromide. Milameline hydrochloride. Oxotremorine M. Oxotremorine sesquifumarate. PD Pridinol Methanesulfonate. PTAC oxalate. Scopolamine butylbromide. Scopolamine hydrobromide. Solifenacin succinate. F igure 6. Western blot analysis of muscarinic receptors m1—m5 in cultured human limbal and conjunctival epithelial cells and fibroblasts. Major bands for m1—m5 were obtained at 55, 50, 55, Depicted are representative data from at least three independent experiments.

Muscarinic receptor

Lane 1 : P0 limbal epithelial cells; lane 2 : P1 conjunctival epithelial cells; lane 3 : P1 conjunctival fibroblasts. F igure 7. The effect of carbachol on conjunctival epithelial cell proliferation. After treatment with carbachol, BrdU incorporation into conjunctival epithelial cells showed a dose-dependent effect and was increased by 1. The fully complemented keratinocytes growth medium increased cell proliferation by 3. F igure 8. The antagonists showed a dose-dependent inhibition of carbachol-induced cell proliferation.

Data are presented as percentage of inhibition of carbachol response over baseline levels. F igure 9. These data were normalized to the amount of total MAPK. Data were expressed as the percentage of increase above basal values, which was set to 1.


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Muscarinic receptors—characterization, coupling and function. Pharmacol Ther. Muscarinic receptor subtypes. Annu Rev Pharmacol Toxicol. Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. The non-neuronal cholinergic system in humans: expression, function and pathophysiology.

Life Sci. Clin Exp Pharmacol Physiol. Muscarinic receptor functioning and distribution in the eye: molecular basis and implications for clinical diagnosis and therapy. Muscarinic receptors binding in retinal pigment epithelium during rat development. Neurochem Res. The effects of acetylcholine and propolis extract on corneal epithelial wound healing in rats. The effect of topical parasympathomimetics on corneal epithelial healing in rabbits. Doc Ophthalmol. Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors.

Exp Eye Res. The uveoscleral outflow routes.

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Muscarinic cholinergic inhibition of adenylate cyclase in the rabbit iris-ciliary body and ciliary epithelium. Invest Ophthalmol Vis Sci.

History of Research on Nicotinic and Muscarinic Cholinergic Receptors

Characterization of muscarinic receptors in human lens cells by pharmacologic and molecular techniques. Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes. Atropine for the treatment of childhood myopia. Multifocal electroretinogram in children on atropine treatment for myopia. Br J Ophthalmol.


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Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells. Curr Eye Res. Characterization of the muscarinic receptor subtypes in the bovine corneal epithelial cells. J Ocul Pharmacol Ther. Am J Physiol. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Expression of muscarinic and adrenergic receptors in normal human conjunctival epithelium. Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion.

Altered expression of neurotransmitter receptors and neuromediators in vernal keratoconjunctivitis. Arch Ophthalmol. Acetylcholine in bovine corneal epithelium. Biochem Pharmacol. Modulation of keratin and connexin expression in limbal epithelium expanded on denuded amniotic membrane with and without a 3T3 fibroblast feeder layer. Human esophageal smooth muscle cells express muscarinic receptor subtypes M 1 through M 5. The in vitro and in vivo proliferative capacity of serum-free cultivated human conjunctival epithelial cells.

Nuclear muscarinic acetylcholine receptors in corneal cells from rabbit.

The Muscarinic Receptors (The Receptors) The Muscarinic Receptors (The Receptors)
The Muscarinic Receptors (The Receptors) The Muscarinic Receptors (The Receptors)
The Muscarinic Receptors (The Receptors) The Muscarinic Receptors (The Receptors)
The Muscarinic Receptors (The Receptors) The Muscarinic Receptors (The Receptors)
The Muscarinic Receptors (The Receptors) The Muscarinic Receptors (The Receptors)
The Muscarinic Receptors (The Receptors) The Muscarinic Receptors (The Receptors)

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